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Incremental Cost-Effectiveness (ICE)
Statistical Inference References

Obenchain RL. Issues and algorithms in cost-effectiveness inference.  Biopharmaceutical Reports 1997; 5: 1-7.  [NOTE: My first ICE paper is now mostly out-of-date in the sense I have since changed key terminology.  Still, it clearly shows that some of my basic ICE concepts that remained unpublished (in a refereed journal) until 2008 are actually much older.View/Download.

Obenchain RL. ICEplane / ICEpairs / ICEpsbbs: Windows software for calculation of bootstrap ICE confidence and tolerance regions and graphical displays on the cost-effectiveness plane.  [Copyright assigned to Pharmaceutical Research and Manufacturers of America (PhRMA.)] 1997-2005.
Two unbiased samples of outcome pairs:  Download ICEplane.
Observed pairs of differences (crossover design):  Download ICEpairs.
Two biased samples (divided into propensity score bins): Download ICEpsbbs. 

Obenchain RL, Melfi CA, Croghan TW, Buesching, DP.  Bootstrap analyses of cost effectiveness in antidepressant pharmacotherapy.  PharmacoEconomics  1997; 11: 464-472.  [Simple application; nothing controversial here.]

Sacristan JA, Obenchain RL.  Reporting cost-effectiveness analyses with confidence.  JAMA 1997; 277: 375.

Obenchain RL, Sacristan JA.  In reply to “The negative side of cost-effectiveness ratios.”  JAMA 1997; 277: 1931-1933.

Obenchain RL, Johnstone BM.  Mixed-model imputation of cost data for early discontinuers from a randomized clinical trial.  Drug Information Journal 1999; 33(1): 191-209. [Contains a simple ICE application in the final section, mostly separate from the main issues of the paper.]

Obenchain RL.  Resampling and multiplicity in cost-effectiveness inference.  J Biopharm Stat 1999; 9(4): 563-582.  View/Download.

Sacristan JA, Gilaberte I, Boto B, Buesching DP, Obenchain RL, Demitrack M, Perez Sola V, Alvarez E, and Artigas F. Cost-effectiveness of fluoxetine plus pindolol in patients with major depressive disorder: results from a randomized, double blind clinical trial. Int Clin Psychopharmacol 2000; 15: 107-113.

Obenchain RL.  The key role of symmetry in cost-effectiveness analyses.  2000 Proceedings of the Biopharmaceutical Section. 15-17.  Alexandria, VA: American Statistical Association.  2001.

Obenchain RL.  Incremental Cost-Effectiveness (ICE) Preference Maps.  2001 JSM Proceedings on CD-ROM.  (10 pages.)  Alexandria, VA: American Statistical Association.  2002.

Obenchain RL, Robinson RL, Swindle RW.  Cost-Effectiveness Inferences from Bootstrap Quadrant Confidence Levels: Three Degrees of Dominance.  J Biopharm Stat 2005; 15(3): 419-436.  View/Download.

Obenchain RL.  ICEinfer: R package for Statistical Inference and Economic Preference variation in Incremental Cost-Effectiveness (ICE) analyzes.  2007-2009.  [Wedge-shaped, equivariant confidence regions (with ICE preference colorings); VAGR acceptability and ALICE curves.]  CRAN, Packages @ http://www.r-project.org  Or... Download Windows package from this site.

Obenchain RL.  ICE Preference Maps: Nonlinear Generalizations of Net Benefit and Acceptability.  Health Services and Outcomes Research Methodology 2008; 8: 31-56. DOI: 10.1007/s10742-007-0027-2,  SpringerLink (free access.)  Erratum (correction to Figure 1):  Health Services and Outcomes Research Methodology 2008; 8: 186. (Not free.)  View/Download PDF (Corrected)

Obenchain RL.  Mathematica NoteBook file deriving and illustrating equations related to 2-parameter and 4-parameter ICE Preference Maps and their Willingness-to-Pay/Accept.  2001-2008.  Download NoteBook file or View/Download PDF copy

Obenchain RL.  JMP DataTable with built-in JSL scrip:  Dynamic Visualization of "Willi-Warp" ...the concept that Willingness-to-Pay (more to get more) and Willingness-to-Accept (less to pay less) can simultaneously vary while the Shadow Price of Health (Lambda) is held fixed (standardized slope = 1, represented by the diagonal line x = y of Axiom 1.)  November 2008. (Requires version 7+ of JMP from SAS.)  Download JMP DataTable

Obenchain RL.  PDF File containing copies of all the ICE Inference Tutorial pages from this web site. [23 pages.] 2008.  View/Download PDF copy

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