Obenchain RL. Issues and algorithms in cost-effectiveness inference. Biopharmaceutical Reports 1997; 5: 1-7. [NOTE: My first ICE paper is now mostly out-of-date in the sense I have since changed key terminology. Still, it clearly shows that some of my basic ICE concepts that remained unpublished (in a refereed journal) until 2008 are actually much older.] View/Download.
Obenchain RL. ICEplane / ICEpairs / ICEpsbbs: Windows software for calculation of bootstrap ICE confidence and tolerance regions and graphical displays on the cost-effectiveness plane. [Copyright assigned to Pharmaceutical Research and Manufacturers of America (PhRMA.)] 1997-2005.
Two unbiased samples of outcome pairs: Download ICEplane.
Observed pairs of differences (crossover design): Download ICEpairs.
Two biased samples (divided into propensity score bins): Download ICEpsbbs.
Obenchain RL, Melfi CA, Croghan TW, Buesching, DP. Bootstrap analyses of cost effectiveness in antidepressant pharmacotherapy. PharmacoEconomics 1997; 11: 464-472. [Simple application; nothing controversial here.]
Sacristan JA, Obenchain RL. Reporting cost-effectiveness analyses with confidence. JAMA 1997; 277: 375.
Obenchain RL, Sacristan JA. In reply to “The negative side of cost-effectiveness ratios.” JAMA 1997; 277: 1931-1933.
Obenchain RL, Johnstone BM. Mixed-model imputation of cost data for early discontinuers from a randomized clinical trial. Drug Information Journal 1999; 33(1): 191-209. [Contains a simple ICE application in the final section, mostly separate from the main issues of the paper.]
Obenchain RL. Resampling and multiplicity in cost-effectiveness inference. J Biopharm Stat 1999; 9(4): 563-582. View/Download.
Sacristan JA, Gilaberte I, Boto B, Buesching DP, Obenchain RL, Demitrack M, Perez Sola V, Alvarez E, and Artigas F. Cost-effectiveness of fluoxetine plus pindolol in patients with major depressive disorder: results from a randomized, double blind clinical trial. Int Clin Psychopharmacol 2000; 15: 107-113.
Obenchain RL. The key role of symmetry in cost-effectiveness analyses. 2000 Proceedings of the Biopharmaceutical Section. 15-17. Alexandria, VA: American Statistical Association. 2001.
Obenchain RL. Incremental Cost-Effectiveness (ICE) Preference Maps. 2001 JSM Proceedings on CD-ROM. (10 pages.) Alexandria, VA: American Statistical Association. 2002.
Obenchain RL, Robinson RL, Swindle RW. Cost-Effectiveness Inferences from Bootstrap Quadrant Confidence Levels: Three Degrees of Dominance. J Biopharm Stat 2005; 15(3): 419-436. View/Download.
Obenchain RL. ICEinfer: R package for Statistical Inference and Economic Preference variation in Incremental Cost-Effectiveness (ICE) analyzes. 2007-2009. [Wedge-shaped, equivariant confidence regions (with ICE preference colorings); VAGR acceptability and ALICE curves.] CRAN, Packages @ http://www.r-project.org Or... Download Windows package from this site.
Obenchain RL. ICE Preference Maps: Nonlinear Generalizations of Net Benefit and Acceptability. Health Services and Outcomes Research Methodology 2008; 8: 31-56. DOI: 10.1007/s10742-007-0027-2, SpringerLink (free access.) Erratum (correction to Figure 1): Health Services and Outcomes Research Methodology 2008; 8: 186. (Not free.) View/Download PDF (Corrected)
Obenchain RL. Mathematica NoteBook file deriving and illustrating equations related to 2-parameter and 4-parameter ICE Preference Maps and their Willingness-to-Pay/Accept. 2001-2008. Download NoteBook file or View/Download PDF copy
Obenchain RL. JMP DataTable with built-in JSL scrip: Dynamic Visualization of "Willi-Warp" ...the concept that Willingness-to-Pay (more to get more) and Willingness-to-Accept (less to pay less) can simultaneously vary while the Shadow Price of Health (Lambda) is held fixed (standardized slope = 1, represented by the diagonal line x = y of Axiom 1.) November 2008. (Requires version 7+ of JMP from SAS.) Download JMP DataTable
Obenchain RL. PDF File containing copies of all the ICE Inference Tutorial pages from this web site. [23 pages.] 2008. View/Download PDF copy